Table 3 List of prolactin biomarkers which overlap with BNT162b2 vaccine-induced DEGs and/or predicted causal proteins.

From: Identifying a causal link between prolactin signaling pathways and COVID-19 vaccine-induced menstrual changes

#

Gene

Overlap confidence score

Activity

Activity prediction p-value GS1

Activity prediction p-value GS2

DEG

1

TNF

3

+

3.80E-11

2.96E-03

Yes

2

MAPK14

3

+

5.46E-07

4.39E-04

Yes

3

PPARA

3

-

9.69E-06

2.97E-05

Yes

4

NFE2L2

3

-

2.32E-03

4.68E-03

Yes

5

TXNIP

3

-

3.81E-03

1.29E-03

Yes

6

IL6R

2

+

3.08E-12

1.37E-04

No

7

GNAS

2

+

9.79E-12

1.79E-05

No

8

GNAI2

2

+

1.53E-10

6.06E-05

No

9

DRD1

2

+

3.56E-09

4.88E-04

No

10

TERT

2

+

9.22E-07

5.48E-06

No

11

S100A6

2

-

1.36E-05

7.83E-05

No

12

FLT1

2

+

2.01E-05

1.63E-04

No

13

CDH1

2

-

3.28E-05

3.64E-04

No

14

MIR516A2

2

+

9.57E-04

8.45E-03

No

15

MIR516A1

2

-

9.57E-04

8.45E-03

No

16

MIF

2

+

9.94E-03

3.60E-03

No

17

VEGFA

1

+

9.58E-10

NA

No

18

E2F1

1

+

1.48E-04

NA

No

19

MIR576

1

-

4.01E-04

NA

No

20

FTO

1

-

3.30E-03

NA

No

21

AHSG

1

+

4.74E-03

NA

No

22

MIR488

1

-

NA

9.72E-06

No

23

CREB1

1

+

NA

2.59E-04

No

24

AKT1

1

+

NA

2.17E-03

No

25

NOS2

1

+

NA

5.91E-03

No

26

TPT1

1

+

NA

6.27E-03

No

27

CASP3

1

-

NA

6.47E-03

No

28

CCL2

1

NA

NA

NA

Yes

29

CD274

1

NA

NA

NA

Yes

30

IFI44

1

NA

NA

NA

Yes

31

MX2

1

NA

NA

NA

Yes

32

IL1B

1

NA

NA

NA

Yes

33

BMPR2

1

NA

NA

NA

Yes

34

PARP1

1

NA

NA

NA

Yes

35

SERPINF2

1

NA

NA

NA

Yes

  1. All molecules were ranked based on their activity prediction p-values as well their overlap confidence score. An overlap confidence score of 3 indicates that a specific gene/protein is overlapping between the biomarker set and 3 other gene sets, while a score of 1 indicates that gene/protein is overlapping between the biomarker list and one other gene set.