Fig. 1: Cellular effector responses to C. burnetii. | npj Vaccines

Fig. 1: Cellular effector responses to C. burnetii.

From: Q fever immunology: the quest for a safe and effective vaccine

Fig. 1

T cell responses are initiated upon peptide-MHC recognition by T cell receptor. Activated T cells differentiate to CD4+ helper T cells that secrete cytokines that activate B cells, macrophages, and inflammation. Activated B cells differentiate to plasma cell that produce antibodies. Antibody effector mechanisms include opsonization and Fc receptor mediated phagocytosis and complement activation.

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