Fig. 2: Vaccine-induced antibody responses to ancestral spike. | npj Vaccines

Fig. 2: Vaccine-induced antibody responses to ancestral spike.

From: Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians

Fig. 2

a IgG levels (AU/ml) and b neutralizing antibody (% inhibition) against ancestral spike protein were measured in serum samples from S-N- [n = 7 for COVISHIELDTM (dark blue); n = 5 for COVAXIN® (dark red)] or S+ and/or N+ [n = 29 for COVISHIELDTM (teal), n = 31 for COVAXIN® (pink)] vaccinees by MSD V-PLEX SARS-CoV-2 panel 1 (IgG) and 25 (ACE2) respectively. c IgG levels (AU/ml) and d neutralizing antibody (% inhibition) against ancestral spike protein in subjects from the S+ and/or N+ group further segregated as N- (n = 15 for both COVISHIELDTM and COVAXIN®) and N+ (n = 14 for COVISHIELDTM and n = 16 for COVAXIN®). Line graphs represent antibody levels at baseline and 2 weeks post-vaccination. Assay cut-off values for each assay are denoted in purple and highest pre-pandemic cut-off in black. Two-way ANOVA with Šídák’s multiple comparisons test was used for statistical analysis.

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