Fig. 7: Quality of vaccine-induced spike specific CD4 + T-cell responses to Wuhan spike using OMIQ. | npj Vaccines

Fig. 7: Quality of vaccine-induced spike specific CD4 + T-cell responses to Wuhan spike using OMIQ.

From: Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians

Fig. 7

Vaccine-induced CD4 + T-cell responses in vaccinated subjects were measured at baseline (D0) and 2 weeks post-vaccination (D98 for COVISHIELDTM) and (D42 for COVAXIN®). a Phenograph clusters expressed by CD4 + T-cells overlaid onto UMAP. b, c Pairwise comparison of numbers of cells expressed within these unique clusters pre- and post-vaccination. d, e Bivariate dot plot showing expression of IFN-γ, IL-2 and CD154 in Cluster 15 and Cluster 20 in COVISHIELD™ and COVAXIN® vaccinees. f, g Bivariate dot plot showing expression of IFN-γ+ and IL-2+ cells within different memory subsets in Cluster 15 and Cluster 20 in COVISHIELD™ and COVAXIN® vaccinees. h, i Pairwise comparison of numbers of cytokine-positive CD4+ cells expressed within these unique clusters pre and post-vaccination. Statistical analyses was performed using a paired Wilcoxon test.

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