Fig. 8: Quality of vaccine-induced spike specific CD8 + T-cell responses to Wuhan spike using OMIQ. | npj Vaccines

Fig. 8: Quality of vaccine-induced spike specific CD8 + T-cell responses to Wuhan spike using OMIQ.

From: Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians

Fig. 8: Quality of vaccine-induced spike specific CD8 + T-cell responses to Wuhan spike using OMIQ.

Vaccine-induced CD8 + T-cell responses in vaccinated subjects were measured at baseline (D0) and 2 weeks post-vaccination (D98) and (D42). a Phenograph clusters expressed by CD8 + T-cells overlaid onto UMAP. b Bivariate dot plot showing expression of IFN-γ, IL-2 and CD137 in Cluster 21 in COVISHIELD™ and COVAXIN® vaccinees. c Pairwise comparison of numbers of cells expressed within the unique clusters pre- and post- vaccination. d Bivariate dot plot showing expression of IFN-γ+ cells within different memory subsets in Cluster 21 in COVISHIELD™ and COVAXIN® vaccinees. e Pairwise comparison of numbers of cytokine-positive CD8 + T-cells expressed within the unique clusters pre- and post-vaccination. Statistical analyses was performed using a paired Wilcoxon test.

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