Fig. 5: HPV mRNA-LNP vaccination drives the functional commitment of CD8+ T cells through IFN-response and exhaustion trajectories. | npj Vaccines

Fig. 5: HPV mRNA-LNP vaccination drives the functional commitment of CD8+ T cells through IFN-response and exhaustion trajectories.

From: mRNA-LNP vaccination-based immunotherapy augments CD8+ T cell responses against HPV-positive oropharyngeal cancer

Fig. 5: HPV mRNA-LNP vaccination drives the functional commitment of CD8+ T cells through IFN-response and exhaustion trajectories.

a Differentiation trajectories inferred using pseudotime and projected onto t-SNE maps. b Expression of inhibitory receptors, memory, effector, proliferation, and IFN-response markers along with three pseudotime trajectories. c Bar plots of cell percentages across treatments (left) and tissues (right) for each trajectory. Data is derived from the therapeutic study in Fig. 4.

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