Fig. 6: Immune responses in mice receiving PSII conjugated to different Qβ VLPs. | npj Vaccines

Fig. 6: Immune responses in mice receiving PSII conjugated to different Qβ VLPs.

From: Proof of concept for a single-dose Group B Streptococcus vaccine based on capsular polysaccharide conjugated to Qβ virus-like particles

Fig. 6

Mice (10 per group) received one (full bars) or two doses (patterned bar) of PSII-CRM, PSII-Qβ, PSII-Qβhp, or RNAse-treated PSII-Qβhp. The geometric mean IgG titer (RLU/mL) is indicated by the bars, individual mice are indicated by the dots, and the 95% Confidence Interval is indicated by the whiskers. For GMT, non responder sera were assigned titers half of the LLOQ. The Wilcoxon signed-ranks test was used to compare titers at day 21 and day 42 of the same immunization group of the same immunization group and the Kruskal–Wallis and Dunn multiple comparisons test was used to compare different immunization groups. **P < 0.01. The corresponding OPKA titers from pools of serum samples are reported below the barchart.

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