Table 3 Mutations of the eight flavivirus-conserved amino acids in the WNV EDI-EDII hinge region.

From: Identification of the flavivirus conserved residues in the envelope protein hinge region for the rational design of a candidate West Nile live-attenuated vaccine

Location

Amino acid substitutions in the E protein

Nucleotide substitutions in the genome position

  

1st codon

2nd codon

3rd codon

Motif #1

A54S

G1126T

  

Motif #2

I130N

 

T1355A

 

I135N

T1370A

Motif #3

V196T

T1553A

 

Y201P

T1567C

A1568C

Motif #4

A269S

G1771T

 

V272T

G1870A

T1871C

 

L281N

T1807A

T1808A

G1809C

  1. Each of the eight flavivirus-conserved hydrophobic residues in the WNV EDI-EDII hinge region was replaced with an amino acid of lower hydrophobicity.
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