Fig. 3: Env-specific serum antibody responses induced by artPICV/artLCMV vaccination. | npj Vaccines

Fig. 3: Env-specific serum antibody responses induced by artPICV/artLCMV vaccination.

From: Immunogenic arenavirus vector SIV vaccine reduces setpoint viral load in SIV-challenged rhesus monkeys

Fig. 3

a Kinetics of binding antibody titers to Env from SIVSME543, SIVSME660 and SIVMAC251 were evaluated during weeks 0–32 of study. b Serum titers of neutralizing antibodies (nAbs) at week 2 after the last vaccine dose (week 30) to pseudoviruses SIVSME543, SME660, MAC239, and challenge virus SIVMAC251. c Antibody titers eliciting ADCC measured at baseline (week 0) and week 30 (2 weeks after the last vaccine dose). Data are represented as geometric mean ± geometric standard deviation. Statistical analysis by two-way analysis of variance (ANOVA) with Dunnett’s post-test (a) and two-sided Wilcoxon matched-pairs signed rank test in (b, c). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Animals with no neutralization (or no 50% inhibitory dose [ID50] value) were arbitrarily assigned a titer of 1 (b) or 120 (c). The dotted lines indicate the limit of detection of the assay.

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