Fig. 5: Antibody durability and functional response elicited by different prime-boost regimens.
From: A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax
a Time courses of the Pvs25-specific antibody responses measured by endpoint dilution ELISA reported as GMT with 95% CI. Time (month) indicates the time after the boost vaccination. n = 8–9 mice per group. b TRA induced by the different immunization regimens at 1- and 7-month post boost vaccination. The experiment was conducted using four different clinical P. vivax isolates (n = 4). TRA was determined at 1:2, 1:10, and 1:50 serum dilutions. c Relationship between TRA (from (b)) and total Pvs-25 specific IgG (Spearman ρ = 0.963, P < 0.0001). Error bars represent SEM in panels (b) and (c). In c, data fit with Hill’s equation.
