Fig. 3: Kinetics of anti-Ova humoral immune responses elicited by pb10-Ova chimeras.
From: Antigen self-anchoring onto bacteriophage T5 capsid-like particles for vaccine design
C57BL/6 mice were immunized by a single subcutaneous injection with pb10-Ova chimeras alone (pO or pNO), bound to T5 CLP (pO- CLP or pNO-CLP) or supplemented with CFA (pO + CFA). Titers of Ova-specific IgG were determined by ELISA at different time points after injection. a–e Each curve represents titers (log2 scale) of individual mice (n = 6) of the indicated group. f Comparison of the kinetics of the different groups (mean + SEM). Titers below 100 were plotted as log2(50). Two-way repeated measures ANOVA was used for comparison of responses between groups with and without CLP, at different time points, then Bonferroni post hoc test was used with p < 0.05 considered significant. ****p < 0.0001 versus pO alone (red) or pNO alone (blue).
