Fig. 4: Nature of the anti-Ova humoral immune responses elicited by pb10-Ova chimeras.
From: Antigen self-anchoring onto bacteriophage T5 capsid-like particles for vaccine design
Mice were immunized subcutaneously by a single injection of pb10-Ova chimeras alone (pO or pNO), bound to T5 CLP (pO-CLP or pNO- CLP) or supplemented with CFA (pO + CFA). Titers of anti-Ova Abs of IgG1 (a), IgG2b (b), IgG2c (c) and IgG3 (d) subtypes were determined by ELISA at day 42 p.i. The results correspond to the mean + SEM of each group (n = 6, log2 scale). Titers below 100 were plotted as log2(50). Results were analyzed using one-way ANOVA followed by Tukey’s multiple comparison test with p < 0.05 considered significant (ns, non-significant; *p < 0.05; ***p < 0.001).
