Fig. 5: Affinity analyses of VRC01-class IGHV1-2 allele variants.
From: Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming
a Affinities of VRC01-class precursors from two bnAb iGLs, four human naive precursors, and four iGLs from week 3 post-vaccination BCRs from IAVI G001, with original *02 or *04 Abs on the left, and W50R variants of those Abs on the right. b Affinities of *02 (N = 71) and *04 (N = 47) iGLs from post-vaccination BCRs from IAVI G001. c Affinities of *02 VRC01-class iGL antibodies from IAVI G001 and for *04 (R66W) variants of the same antibodies (N = 28 each). Lines connect matched Ab variants. In (a, b), horizontal lines indicate median and interquartile range. In (a–c), all affinities were measured for eOD-GT8 monomer analyte, and all iGLs from IAVI G001 are from the low dose group.
