Table 1 Experimental design of five reduction in liver infection experiments showing group sizes

From: Establishing RTS,S/AS01 as a benchmark for comparison to next-generation malaria vaccines in a mouse model

Experiment ID

Administrations (in vaccine groups)

Control groups (# mice/group)

Vaccine groups (# mice/group)

AB317

Naïve (No vaccine)

Background (d-luciferin)

RTS,S dose levels

0.05 μg

0.2 μg

1 μg

5 μg

10 μg

2x Trial 1

2

5

5

2

5

5

5

5

5

2x Trial 2

2

5

5

2

5

5

5

5

5

2x Trial 3

2

5

5

2

5

5

5

5

5

3x Trial 1

3

5

5

2

5

5

5

5

5

3x Trial 2

3

5

5

2

5

5

5

5

5

  1. Different doses of RTS,S in a constant amount of AS01 adjuvant were administered intramuscularly at 3-week intervals, with IV challenge from 2000 tgPb-PfCSP sporozoites 2-weeks after the last vaccination. For the AB317 groups, only one administration was given 16 h prior to challenge.