Table 4 Experimental design and protection results of four mosquito bite challenge experiments

From: Establishing RTS,S/AS01 as a benchmark for comparison to next-generation malaria vaccines in a mouse model

Experiment ID

Total administrations

AB317

Naïve (no vaccine)

RTS,S dose levels

0.05 μg

0.2 μg

1 μg

5 μg

10 μg

RTS,S 2x

2

5/7

71.4%

0/7

0%

0/7

0%

0/7

0%

0/7

0%

0/7

0%

1/7

14.3%

RTS,S 3x-1

3

5/7

71.4%

1/7

14.3%

3/7

42.9%

3/7

42.9%

3/7

42.9%

4/7

57.1%

3/7

42.9%

RTS,S 3x-2

3

4/7

57.1%

0/7

0%

0/7

0%

0/7

0%

1/7

14.3%

5/7

71.4%

1/7

14.3%

RTS,S 3x-3

3

6/7

85.7%

0/7

0%

1/7

14.3%

2/7

28.6%

3/7

42.9%

4/7

57.1%

6/7

85.7%

  1. Results are shown as the fraction and percentage of protected mice over the number challenged. Experimental ID represents the immunogen (RTS,S), the number of administrations (eg 2x = two administrations, and the individual experiment number (eg -1)). For the AB317 groups, only one administration was given 16 h prior to challenge.
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