Fig. 1: Risk differences (RDs, center) and 95% confidence intervals (CIs, length of error bars) between vaccinated and unvaccinated (ref) participants for self-reported physical, cognitive, and fatigue symptoms.

Vaccinated participants refer to individuals who completed their primary course prior to responding to a follow-up questionnaire. Symptoms were self-reported between September 1, 2021 and May 6, 2022. Nunvacinated = 1568, Nvaccinated = 34,838; Fatigue track (F): based on the Fatigue Assessment Scale and select questions from Depaul Symptom Questionnaire (N = 4375, nunvaccinated = 256, nvaccinated = 4119); Physical track (Ph): based on select questions from the 36-Item Short Form Survey Instrument (N = 9572, nunvaccinated = 520, nvaccinated = 9052); Cognitive track (C): based on the Cognitive Complaints in Bipolar Disorder Rating Assessment (N = 4,568, nunvaccinated = 253, nvaccinated = 4315).