Fig. 6: mRNA-LNP vaccine candidates, encoding VZV gE, induces antigen-specific LLPCs and T (TMEM) cell memory responses in mice. | npj Vaccines

Fig. 6: mRNA-LNP vaccine candidates, encoding VZV gE, induces antigen-specific LLPCs and T (TMEM) cell memory responses in mice.

From: Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine

Fig. 6

C57Bl/6 mice (5 animals per group) were primed with live attenuated VZV vaccine (Varivax®), and vaccinated twice, 4 weeks apart, with the mRNA-LNP vaccine candidates or Shingrix®. Immunological memory was evaluated 16 weeks post last immunization. A Long lived plasma cells in the bone marrow secreting antibodies that bind to VZV gE, quantified by B cell ELISpot assay. Y-axis represents Spot Forming Cells (SFCs) per million bone marrow-derived cells. B Percentages of effector memory CD4+CD44+CD62L- T cells (Y-axis) secreting either IFN-γ, TNF-α, and IL-2 alone or any of the two or all three cytokines. Data shown as Mean ± SEM.

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