Fig. 8: Bivalent boosting temporarily improved CD4+ T-cell polyfunctionality in pSOTRs. | npj Vaccines

Fig. 8: Bivalent boosting temporarily improved CD4+ T-cell polyfunctionality in pSOTRs.

From: COVID-19 vaccination induces distinct T-cell responses in pediatric solid organ transplant recipients and immunocompetent children

Fig. 8: Bivalent boosting temporarily improved CD4+ T-cell polyfunctionality in pSOTRs.

a Cytokine production by CD4+ T cells in response to ancestral and Omicron BA.4/5 peptides at days 0, 14, and 300 post-bivalent vaccination. Pie charts depict the 15 cytokine combination categories. Arcs identify slices of the pie that express each specific cytokine. b Heatmap identifying absolute differences between groups for each category. c Frequencies of CD4+ T cells producing cytokine combinations in response to ancestral or BA.4/5 peptide stimulation. Two-way ANOVA with Tukey correction, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Error bars represent standard error of the mean.

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