Fig. 7: Prophylactic immunization with Lip-OVA58-72 reduced anaphylactic responses in OVA-allergic mice. | npj Vaccines

Fig. 7: Prophylactic immunization with Lip-OVA58-72 reduced anaphylactic responses in OVA-allergic mice.

From: T cell independent antibody responses with class switch and memory using peptides anchored on liposomes

Fig. 7

BALB/c mice (n = 5) were immunized twice (weeks 0 and 4) with Lip-OVA58-72 or OVA protein on alum (Alu-OVA) or left untreated (No immunization). On weeks 8 and 11, all mice were subject to sensitization with OVA protein on alum. One group of non-immunized mice were left non-sensitized (No sensitization). On week 14, all mice were challenged intraperitoneally with soluble OVA and the body temperature monitored as a measure for allergic anaphylaxis; the integrated AUC for the body-temperature curves was calculated using pre-challenge temperature as baseline. Results are expressed as mean + SEM and analyzed using Kruskal-Wallis tests comparing the two immunized groups to the non-immunized group. Statistical p values are indicated.

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