Table 1 Targets and functions of the viral components involved in immune evasion during MD infection
From: Immune escape of avian oncogenic Marek’s disease herpesvirus and antagonistic host immune responses
Category | Viral components | Viral/host targets | Potential role and functions | Refs. |
|---|---|---|---|---|
Modulation of MHC | MDV012 | TAP | downregulation of MHC-I molecules expressions | |
pUL.49.5 | TAP | downregulation of MHC-I molecules expressions | ||
UD | UD | upregulation of MHC-II molecules expressions | ||
UD | IFN-γ-receptor complex | downregulation of MHC-II molecules expressions | ||
Promote latency | meq | Bcl-2 | inhibits infected cells apoptosis | |
pp38-pp24 | prevents viral DNA replication and productive infection | |||
vTR | chTERT | inhibits infected cells apoptosis | ||
miR-M7-5p | ICP4/ICP27 | prevents viral DNA replication | ||
miR-M4-5p | UL28 | prevents viral DNA replication | ||
JARID2 | promote infected cells survival | |||
miR-M4-3p | UL32 | prevents viral DNA replication | ||
miR-M5-3p | ICP22 | prevents viral DNA replication | ||
UD | IKFZ1 | maintenance of the latency | ||
Telomeric integration | mTMR | / | facilitates viral genome integration | |
sTMR | / | facilitates viral genome integration | ||
vTR | chTERT | participates in MDV integration | ||
Meq | c-Myc | participates in MDV integration | ||
VP22 | UD | induces DNA lesions |
