Table 1 Clinical and Biochemical characteristics of the study subjects at all time points

From: Calcifediol boosts efficacy of ChAdOx1 nCoV-19 vaccine by upregulating genes promoting memory T cell responses

 

Baseline

3rd Month

6th Month

Characteristic

Placebo (N = 12)

Calcifediol (N = 12)

p value

Placebo (N = 12)

Calcifediol (N = 12)

p value

Placebo (N = 12)

Calcifediol (N = 12)

p value

Sex (female)

4

6

–

–

–

–

–

–

–

Age (years)

28.2 ± 9.1

35.8 ± 10

–

–

–

–

–

–

–

25(OH)D (ng/ml)

13.91 ± 5.98

11.39 ± 6.9

0.72

15.71 ± 6.95

134.9 ± 42.8

<0.0001

13.4 ± 5.94

85.01 ± 34.49

<0.0001

Δ t-baseline 25(OH)D

–

–

–

1.79 ± 5.73

123.53 ± 38

<0.0001

−0.51 ± 9.65

73.62 ± 31.8

<0.0001

Calcitriol (pmol/l)

134.84 ± 34.1

113.5 ± 32

0.34

132.14 ± 43.38

165.04 ± 53.24

0.29

120.5 ± 47.2

155.6 ± 50.6

0.25

Δ t-baseline Calcitriol

–

–

–

−2.7 ± 59.6

51.54 ± 49.78

0.03

−14.31 ± 49.71

42.14 ± 48.35

0.02

iPTH (pg/ml)

60.34 ± 28.67

53 ± 19.97

0.85

65.65 ± 37.08

38.1 ± 13.3

0.04

59.72 ± 26.16

52.5 ± 12.1

0.78

Δ t-baseline iPTH

–

–

–

5.3 ± 21.47

−18.47 ± 19.31

0.01

−0.61 ± 19.57

−0.45 ± 16.93

0.99

Calcium (mg/dl)

8.89 ± .08

9.37 ± 0.3

0.22

9.39 ± 0.5

9.55 ± 0.5

0.83

9.38 ± 0.6

9.61 ± 0.3

0.55

Δ t-baseline Calcium

–

–

–

0.5 ± 0.92

0.17 ± 0.4

0.52

0.48 ± 1.14

0.23 ± 0.4

0.68

  1. The 25(OH)D, intact parathyroid hormone (iPTH) and calcitriol levels were measured in plasma while the calcium levels were determined in serum specimens. Δ t-baseline: Values of 3rd and 6th month with respect to baseline, where “t = 3rd or 6th month.” The data is shown as mean ± standard deviation (SD).
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