Table 2 List of main biological processes and the genes involved that were found differentially upregulated upon calcifediol supplementation
Biological Processes | Upregulated Genes |
|---|---|
Activation of innate immune response | PRKDC, SFPQ, MATR3, SIN3A |
Regulation of innate immune response | XIAP, CASP8, LRP8, N4BP1, SAMHD1, APPL1, APPL2 |
Positive regulation of T cell chemotaxis | ADAM10, ADAM17, OXSR1, WNK1 |
T cell receptor signaling pathway | PDE4D, PIK3CA, PLCG2, PTPRJ, TRAF6, TXK, MALT1, PTPN22, RC3H2, WNK1, RC3H1, DENND1B |
Defense response to virus | BCL2, LYST, DHX15, IFNAR2, NCBP1, EIF2AK2, RNASEL, PLA2G10, G3BP1, ZMYND11, CARD8, DDX58, SAMHD1, SETD2, TLR7, IFIH1, TRIM56, TRIM52, SLFN11, MLKL, PDE12, SERINC5, NLRP9, GBP7 |
Cellular response to virus | CHUK, MAPK14, DDX3X, FMR1, HIF1A, IL12A, LGALS8, RIOK3, IFIH1 |
Cytokine-mediated signaling pathway | CBL, IL6ST, JAK2, KIT, PTPN11, PTPRJ, SOS1, IRAK3, IL31RA |
Notch signaling pathway | ADAM10, NOTCH2, MAML2 |
B cell receptor signaling pathway | BCL2, CD38, CTLA4, NFATC2, PLCG2, TEC, VAV3, BANK1, PLEKHA1 |
Calcium ion transmembrane transport | ATP2A2, ATP2B4, ITGAV, P2RX7, PKD2, RYR3, SLC8A1, TRPC1, TRPC5, SLC24A1, TRPM7, MCOLN3, TRPM6, ANO6, MCOLN2 |
Memory T cell responses | EOMES, ID3, ADAM23, EPHA4, ITK, BCL11B, PRDM1, CCR6, ZNF365, TGFBR3, DOCK9, INPP4B, EPHA4, ITK, BCL11B, PRDM1, PPP2R2B, SLFN5, FBXO32 |
