Fig. 7: LVRNA001 caused no toxic effects in a reproductive toxicity study in rats.
From: Safety and efficacy assessment of an mRNA rabies vaccine in dogs, rodents, and cynomolgus macaques
a Schematic diagram depicting the reproductive toxicity study schedule for rats. F0 males were immunized i.m. with LVRNA001 (25 or 50 μg), Empty LNP, or Saline on D0, D7, D21, and D35. EFD phase F0 females were immunized i.m. with LVRNA001 (25 or 50 μg), Empty LNP, or Saline on D14 (28 days prior to pairing for mating), D21, D35, and on gestation day 6 (GD6). After mating, littering phase F0 females received LVRNA001 (25 or 50 μg), Empty LNP, or Saline on D14 (28 days prior to pairing for mating), D21, D35, GD6, and postnatal day 7 (PND7). b Statistics of parent female rats after cesarean delivery (GD20 autopsy) and F1-generation rats. c Uterine and placenta weight. d The number of live fetuses. e Lactation index (the proportion of pups alive on PND4 who were alive on PND21). Error bars represent standard deviation (c, d, e). Statistical analysis was performed using an ordinary one-way ANOVA.
