Fig. 10: Qualitative representation of outcomes of vaccination with recombinant CCHFV proteins. | npj Vaccines

Fig. 10: Qualitative representation of outcomes of vaccination with recombinant CCHFV proteins.

From: Crimean Congo hemorrhagic fever virus nucleoprotein and GP38 subunit vaccine combination prevents morbidity in mice

Fig. 10

Schematic summary of the immune responses and protective efficacy of each vaccine. IgM and IgG responses, ADCD, and ADCP functions of antibodies and T-cell response were used as indicators of immune response. Clinical chemistry profiles, improved clinical outcome, reduced histopathology of liver and spleen, and survival were used as indicators of protective efficacy. To describe the strength of humoral immune responses and protection from lethal disease, the following scale was used: absent (−), mild (+), moderate (++), and strong (+++). Graphical illustrations were prepared with BioRender (www.biorender.com).

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