Fig. 1: Key amino acid alterations in the HA proteins of H5 viruses. | npj Vaccines

Fig. 1: Key amino acid alterations in the HA proteins of H5 viruses.

From: A broad-spectrum vaccine candidate against H5 viruses bearing different sub-clade 2.3.4.4 HA genes

Fig. 1: Key amino acid alterations in the HA proteins of H5 viruses.

a Alignment of HA1 protein sequences (H5 numbering). Antigenic regions A, B, C, D, and E are delineated and highlighted in orange, green, cyan, blue, and pink, respectively. Sites with amino acid variations are marked and highlighted in red. b The site exhibiting amino acid variation is depicted in the HA monomer of an H5 virus, retrieved from the PDB database (5HUF). Amino acid substitutions at antigenic sites are denoted in red, and the respective antigenic regions are marked with corresponding colors.

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