Fig. 3: NiV G nanoparticle elicits cross-reactive neutralizing responses. | npj Vaccines

Fig. 3: NiV G nanoparticle elicits cross-reactive neutralizing responses.

From: An attachment glycoprotein nanoparticle elicits broadly neutralizing antibodies and protects against lethal Nipah virus infection

Fig. 3

a, c The serum cross-binding against recombinant NiV-B and HeV G head domain was measured by ELISA at Day 61 (~three weeks after the third immunization). The serum neutralizing titers against pseudotyped NiV-B (b) and HeV (d) at ~three weeks post the second (Day 42) and third (Day 61) immunizations were determined by pseudovirus neutralization assay. The numbers above the symbols indicate the geometric mean titers (GMTs). Dashed lines indicate the limit of detection (LOD) of the assays. The values lower than LOD were calculated as half of LOD. Experiments are performed in duplicate wells, and data from each group are shown as geometric mean with geometric SD. Statistical significance was determined by the one-way ANOVA with Tukey’s multiple comparisons test. ns not significant, *p < 0.05, **p < 0.01, ***p < 0.001.

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