Fig. 2: The V2 loop sequence of SHIV-SF162P3 is highly similar to the Mos1 vaccine strain.
From: Mosaic HIV-1 vaccine and SHIV challenge strain V2 loop sequence identity and protection in primates
a Env sequence alignment consisting of the V2 loop and the V2 hotspot regions for the NHP challenge strain SF162P3 and vaccine strains, Mos1, Mos2S, and C97ZA. Colors highlight amino acid disagreements within alignment and each color represents a unique amino acid residue. b Distance matrix showing % identity of V2 loop sequences shown in (a). c–e frequency distribution of the analyzed circulating clade B (N = 2887) (c) or clade C (N = 1717) (d) or M group T/F (N = 410) (e) strains, based on identity of their V2 loop and V2 hotspot the Mos1 (upper panels) or C97ZA (lower panels) vaccine strains. Black dotted lines depict the SHIV-SF162P3 challenge strain and colored dotted lines represent the circulating strain median in each graph. Numbers on lines above the graphs depict the corresponding % identity to either Mos1 or the C97ZA reference strain. NHP non-human primate, T/F transmitter founder.
