Fig. 3: Immunogenicity of A/Singapore/INFIMH-16-0019/2016 N2 and A/Michigan/45/2015 N1 rTET-NAs in naïve and pre-infected ferrets. | npj Vaccines

Fig. 3: Immunogenicity of A/Singapore/INFIMH-16-0019/2016 N2 and A/Michigan/45/2015 N1 rTET-NAs in naïve and pre-infected ferrets.

From: Boosting neuraminidase immunity in the presence of hemagglutinin with the next generation of influenza vaccines

Fig. 3

Sera were collected three weeks after initial dose or prime and three weeks after booster vaccination and tested via ELLA to assess NAI antibody activity using reassortant H6N2 A/Singapore/INFIMH-16-0019/2016 (A–C) or H6N1 A/Michigan/45/2015 (D–F) viruses as sources of sialidase, respectively. In A, B and D, E, º symbol represents IC50 NAI titers three weeks after initial prime (D21), ■ represents IC50 NAI titers three weeks after booster (D42), while dashed lines represent starting sera dilution or lower limit of detection for ELLA assay. The solid lines represent the average measurement. In C and F, all symbols represent boost/prime ratio for individual animals in the indicated vaccine groups, while the bar represents average ratio per vaccine group. *p < 0.05; **p < 0.01; ***p < 0.001 (the red text/symbols are comparisons vs PBS/control).

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