Fig. 5: Histopathology of liver and lung tissues support in vivo attenuation of rLASV/IGR-CD.
From: A Lassa virus live attenuated vaccine candidate that is safe and efficacious in guinea pigs
Representative images of H&E and IHC staining of liver tissues and ISH staining of lung tissues taken at necropsy during the study depicted in Fig. 3. Black arrows depict liver degradation and single-cell necrosis (A, top), viral antigen (A, middle), and viral RNA in a single cell (A, bottom; B, bottom). CD codon-deoptimized; H&E hematoxylin and eosin; IHC immunohistochemistry; ISH in situ hybridization; LASV Lassa virus; rLASV recombinant LASV; WT wild-type.
