Fig. 4: Differential abundances of γδ T cell subsets between vaccine low and high responders. | npj Vaccines

Fig. 4: Differential abundances of γδ T cell subsets between vaccine low and high responders.

From: Mass cytometry reveals cellular correlates of immune response heterogeneity to SARS-CoV-2 vaccination in the elderly

Fig. 4

a UMAP of reclustered γδ T cells colored according to the clusters identified by surface antigen expression. b Marker expression used for delineating the 9 metaclusters visualized in UMAP space. c Histograms of selected surface antigens and cytokines to establish the phenotype of the identified clusters. d Boxplots of frequencies of different γδ T cell subsets in low (LR) and high (HR) responders in post-vaccination samples being unstimulated, spike or Cytostim-stimulated in vitro. Comparison of frequencies was done by modeling counts of clusters by negative binomial regression. An FDR-adjusted p < 0.1 was considered statistically significant. The reported frequencies are calculated as % of total live PBMCs.

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