Fig. 5: The comparison of rabies virus (RABV)-specific interleukin-4 (IL-4) and interferon-gamma (IFN-γ) producing T cells between RABV-exposed versus RABV-unexposed individuals at various timepoints after post-exposure prophylaxis (PEP) using the Institut Pasteur du Cambodge (IPC) regimen.
From: Evaluation of one year immunity following rabies post-exposure prophylaxis in dog bite cases
The fluorospot assay was used to determine IL-4 (A) and IFN-γ (B) secreting cells expressed as spot-forming cells (SFCs) at baseline (D0), day 7 (D7), day 14 (D14), month 6 (M6), and month 12 (M12) after PEP in RABV-exposed group (red, n = 17) and RABV-unexposed group (blue, n = 19). Each dot represents a single individual. Data was transformed into logarithmic scales before being used in statistical analysis for visualization purposes. Red and blue lines represent the median and interquartile range. PBMCs, human peripheral blood mononuclear cells. Statistics: Mann-Whitney test. Asterisks represent significance levels as follows: *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.
