Fig. 7: Antigen-specific total IgG titres and opsonization activity induced by subcutaneous immunisation.
From: A synthetic cyclic peptide for promoting antigen presentation and immune activation
a Total IgG titre (log 10) specific to J8, 88/30, or NS1 on day 27, following primary immunisation and one boost, as determined by ELISA. b Total IgG titres (log 10) on day 41, following primary immunisation and three boosts, measured by ELISA. Each point represents an individual mouse, with bars indicating the average antigen-specific serum IgG antibody titres. c Average opsonisation percentage of various GAS strains by serum collected on day 41 from immunised mice. Results are represented as the opsonisation percentage relative to reference untreated wells, with error represented as the SEM. Mice (n = 5 per group) were immunised with vaccine candidates (Table S1), negative control (PBS) and positive controls (antigen-PADRE + CFA). Statistical analysis was performed using a one-way ANOVA followed by Tukey post-hoc test (ns, p > 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001).
