Fig. 5: Impact of SUB knockdown on gene expression related to the inflammatory response in the skin during SFTSV transmission. | npj Vaccines

Fig. 5: Impact of SUB knockdown on gene expression related to the inflammatory response in the skin during SFTSV transmission.

From: Haemaphysalis longicornis subolesin controls the infection and transmission of severe fever with thrombocytopenia syndrome virus

Fig. 5

The expressions of proinflammatory cytokines and chemokines (A), as well as the inflammatory monocyte markers (B), were analyzed in the skin bitten by SUB-knockdown female ticks compared with control ticks using qPCR analysis. TLR4 Toll-like receptor 4, TRAF6 TNF receptor-associated factor 6, IFNGR2 interferon gamma receptor 2, TREM1 triggering receptor expressed on myeloid cells 1, CCR3 C-C motif chemokine receptor 3, CCL2 chemokine C-C motif ligand 2. Statistical significance was determined using the Mann–Whitney tests for CCL2 and Student’s t-tests for the others (n = 5 per group). **p < 0.01; n.s. not significant.

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