Fig. 2: The mRNA vaccine induced strong immune responses in BALB/c and K18-hACE2 mice.
From: mRNA vaccines with RBD mutations have broad-spectrum activity against SARS-CoV-2 variants in mice
a Schematic diagram of the immunization process in BALB/c mice. b The expression levels of cytokines at 5 h and 24 h postimmunization, with ρ indicating the serum concentration of cytokines (pg/mL) (n = 4). c ELISA results showing the levels of BA.2 RBD-specific binding antibodies in BALB/c mice (n = 5). d Immunization process in K18-hACE2 mice. e ELISA results for BA.2 RBD-specific binding antibodies in K18-hACE2 mice (Placebo: n = 5, BSCoV 05, BSCoV06 and BA.1: n = 4). The detection limit of the ELISA is 200 and the schematic diagram of the immune process was obtained from the BioRender website, “ns” means no significant difference.
