Fig. 3: Neutralization activity of BSCoV05- and BSCoV06-induced antibodies against each strain.
From: mRNA vaccines with RBD mutations have broad-spectrum activity against SARS-CoV-2 variants in mice
a–c The GMTs of neutralizing antibodies against different strains in the serum of BALB/c mice immunized with BSCoV05, BSCoV06, and BA.1. d The titers of neutralizing antibodies against various pseudoviruses in the serum of BALB/c mice immunized with BSCoV06 or BA.1. e The neutralizing antibody titers against various live strains in the serum of K18-hACE2 mice 42 days postimmunization with each vaccine. (Placebo: n = 5, BSCoV 05,BSCoV06 and BA.1: n = 4) The data are expressed as means ± SEM. Statistical analysis was conducted using one-way ANOVA and Tukey’s multiple comparison test. The significance of differences between the experimental group and the unimmunized control group is indicated by asterisks, the significance of no marker indicates no significance. *P < 0.05, **P < 0.01, ***P < 0.005. The detection limit of the authentic virus neutralization experiment is 16 and the pseudovirus neutralization experiment is 20 as indicated by the red dashed line.
