Fig. 4: Statistical plots of the ELISPOT results.
From: mRNA vaccines with RBD mutations have broad-spectrum activity against SARS-CoV-2 variants in mice
a–c The number of IFN-γ-specific spots generated after stimulation in each group (n = 5). d–f The number of IL-2-specific spots produced following stimulation in each group (n = 5). g–i The number of IL-4-specific spots generated after stimulation in each group (n = 5). The data are expressed as the means ± SEMs. Statistical analysis was conducted via one-way ANOVA and Tukey’s multiple comparison test. The significance of differences between the experimental group and the unimmunized control group is indicated by asterisks, and the significance of no marker indicates no significance. *P < 0.05, **P < 0.01, ***P < 0.005.
