Fig. 7: 6x-His-LY-CS:P NPs, 6x-His-KT-CS:P NPs, and 6x-His-BD-CS:P NPs induce systemic humoral immune responses in BALB/c mice. | npj Vaccines

Fig. 7: 6x-His-LY-CS:P NPs, 6x-His-KT-CS:P NPs, and 6x-His-BD-CS:P NPs induce systemic humoral immune responses in BALB/c mice.

From: Cyclic di AMP phosphodiesterase nanovaccine elicits protective immunity against Burkholderia cenocepacia infection in mice

Fig. 7

Mice were immunized subcutaneously with a prime dose and two booster intranasal doses of A 6x-His-LY-CS:P NPs, B 6x-His-KT-CS:P NPs, C 6x-His-BD-CS:P NPs, and adjuvant (CS:P). Two weeks following the last dose, mice (n = 7 per group) were sacrificed, sera collected, and the IgG antibodies were detected using indirect ELISA. The Y-axis represents the endpoint titers; the error bars indicate S.D. The unpaired t-test was used to determine the significance of the antibody titer; the asterisk refers to statistically significant differences as follows: (**) p-value < 0.01, and (***) p-value < 0.001.

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