Fig. 4: Qβ vaccines against heroin metabolites protect against heroin-induced anti-nociception. | npj Vaccines

Fig. 4: Qβ vaccines against heroin metabolites protect against heroin-induced anti-nociception.

From: Two doses of Qβ virus like particle vaccines elicit protective antibodies against heroin and fentanyl

Fig. 4: Qβ vaccines against heroin metabolites protect against heroin-induced anti-nociception.

A Anti-nociceptive responses measured by tail-flick assay in Balb/cJ mice immunized with Qβ-morphine, Qβ-6AM, Qβ-Combo, Qβ control, or PBS control challenged with heroin (0.5 mg/kg, s.c.) at 3-weeks post-second immunization and tested over a 90 min time course. % Maximum Possible Effect (%MPE = [(drug – basal response)/(20 s – basal response time)] x 100%). B Tail-flick anti-nociceptive responses analyzed at 30 min post-injection with heroin (0.5 mg/kg, s.c.). *p = 0.0364; ***p = 0.0003; vs. PBS control; Kruskal-Wallis test, GraphPad Prism.

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