Fig. 2: CoVEXS5 protects against severe SARS-CoV-2 infection in mice. | npj Vaccines

Fig. 2: CoVEXS5 protects against severe SARS-CoV-2 infection in mice.

From: An adjuvanted chimeric spike antigen boosts lung-resident memory T-cells and induces pan-sarbecovirus protective immunity

Fig. 2: CoVEXS5 protects against severe SARS-CoV-2 infection in mice.

A K18-hACE2 mice (n = 6) were immunised twice with sham (PBS) or CoVEXS5 at 5, 1 or 0.1 μg of CSA05 formulated 1:1 with SWETM and at 28 days challenged with 1 × 103 PFU SARS-CoV-2 Delta. B Clinical scores at day 6 post-infection. C Percentage of initial body weight loss in male K18-hACE2 mice (n = 6/group). D Total inflammatory cells in bronchoalveolar lavage fluid (BALF). E Viral titres in BALF, lung or brain homogenates were determined using plaque assay. Significant differences between placebo and vaccinated group were determined by one-way ANOVA with Tukey’s multiple comparison test; **p < 0.01, ***p < 0.001. A created with Biorender.

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