Fig. 4: Broad sarbecovirus immunity after CoVEXS5-boosting in mice. | npj Vaccines

Fig. 4: Broad sarbecovirus immunity after CoVEXS5-boosting in mice.

From: An adjuvanted chimeric spike antigen boosts lung-resident memory T-cells and induces pan-sarbecovirus protective immunity

Fig. 4: Broad sarbecovirus immunity after CoVEXS5-boosting in mice.

C57BL/6 mice (n = 6) were vaccinated i.m. with two doses of Comirnaty Original/Omicron BA.4/5 (mRNA-BV) at 2 weeks apart (0.05 or 5 μg per dose) (A) and kinetics of neutralising antibody (nAb) responses (B) or spike-specific T-cells secreting IFN-γ (C) were determined. Mice that received the 0.05 μg dose of mRNA-BV were boosted 7 weeks later with two doses of CoVEXS5 (1 μg) or Comirnaty XBB.1.5 (mRNA-XBB; 5 μg). Pre-and post-nAb levels were determined using a panel of spike-pseudotyped viruses representing SARS-CoV-2 variants (D) or non-SARS-CoV-2 sarbecoviruses (E). Numbers represent the fold change between pre- and post-boost nAb levels. A created with Biorender.

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