Table 3 Seven- and thirty-day outcomes in propensity-matched COVID-19-associated stroke cases at two different timepoints
From: Vaccination against COVID-19 and Outcomes in Patients with COVID-19 Infection and Stroke
Part 1: April 1, 2021 to November 30, 3021 (Delta variant period) | Part 2: December 01, 2021 to September 30, 2022 (Omicron variant period) | |||||
|---|---|---|---|---|---|---|
Vaccinated N = 1543 Events / Subjects (% Risk) | Unvaccinated N = 1543 Events / Subjects (% Risk) | HR (95% CI), P value, log rank test | Vaccinated N = 2083 Events / Subjects (% Risk) | Unvaccinated N = 2083 Events / Subjects (% Risk) | HR (95% CI) P value, log rank test | |
7 days outcomes | ||||||
All-cause mortality | 42 / 1543 (2.7%) | 56 / 1543 (3.6%) | 0.74 (0.50, 1.10) | 81 / 2083 (3.9%) | 102 / 2083 (4.9%) | 0.78 (0.59, 1.05) |
Intracranial hemorrhage* | 51 / 1399 (3.6%) | 97 / 1390 (7.0%) | 0.52 (0.37, 0.73) | 86 / 1917 (4.5%) | 109 / 1923 (5.7%) | 0.79 (0.59, 1.04) |
Venous thromboembolic events* | 38 / 1205 (3.2%) | 114 / 1219 (9.4%) | 0.33 (0.23, 0.48) | 59 / 1631 (3.6%) | 136 / 1695 (8.0%) | 0.44 (0.33, 0.60) |
Acute myocardial infarction* | 53 / 1225 (4.3%) | 107 / 1264 (8.5%) | 0.50 (0.36, 0.70) | 67 / 1684 (4.0%) | 132 / 1719 (7.7%) | 0.51 (0.38, 0.69) |
G-tube placement* | 10 / 1514 (0.7%) | 13 / 1512 (0.9%) | 0.61 (0.25, 1.47) | 10 / 2041 (0.5%) | 14 / 2063 (0.7%) | 0.43 (0.16, 1.11) |
Mechanical ventilation* | 55 / 1425 (3.9%) | 73 / 1455 (5.0%) | 0.76 (0.54, 1.08) | 102 / 1932 (5.3%) | 92 / 1976 (4.7%) | 1.13 (0.85, 1.50) |
30-days outcomes | ||||||
All-cause mortality | 110 / 1543 (7.1%) | 122 / 1543 (7.9%) | 0.87 (0.67, 1.12) | 195 / 2083 (9.4%) | 201 / 2083 (9.7%) | 0.93 (0.77, 1.14) |
Intracranial hemorrhage* | 56 / 1399 (4.0%) | 107 / 1390 (7.7%) | 0.51 (0.37, 0.71) | 96 / 1917 (5.0%) | 115 / 1923 (6.0%) | 0.83 (0.63, 1.09) |
Venous thromboembolic events* | 48 / 1205 (4.0%) | 131 / 1219 (10.7%) | 0.36 (0.26, 0.50) | 80 / 1631 (4.9%) | 156 / 1695 (9.2%) | 0.52 (0.40, 0.68) |
Acute myocardial infarction* | 60 / 1225 (4.9%) | 116 / 1264 (9.2%) | 0.52 (0.38, 0.71) | 77 / 1684 (4.6%) | 141 / 1719 (8.2%) | 0.55 (0.41, 0.72) |
G-tube placement* | 29 / 1514 (1.9%) | 33 / 1512 (2.2%) | 0.85 (0.52, 1.40) | 28 / 2041 (1.4%) | 43 / 2063 (2.1%) | 0.63 (0.39, 1.01) |
Mechanical ventilation* | 71 / 1425 (5.0%) | 93 / 1455 (6.4%) | 0.77 (0.56, 1.04) | 116 / 1932 (6.0%) | 100 / 1976 (5.1%) | 1.18 (0.90, 1.54) |
