Fig. 3: Immune responses induced by the saRNA-gD vaccine in piglets.
From: A self-amplifying mRNA vaccine expressing PRV gD induces robust immunity against virulent mutants
a Experimental design for vaccination and challenge, piglets were immunized on d 0 and 28dpi and challenge-infected on 42 dpi. Schematics created with BioRender.com. b Serum-neutralizing antibodies against PRV were measured weekly after immunization. c, d The levels of IL-4 and IFN-γ in the serum were measured at 14 and 35 dpi (data are presented as mean ± SD (n = 3 per group). Statistical significance was determined by one-way ANOVA followed by Tukey’s multiple comparisons test: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).
