Fig. 11: Schematic diagram of interferon (IFN)-sensitive viruses.
From: Synthetic biology-inspired development of live attenuated influenza vaccines
Mutations were introduced into the viral genome to engineer a hyper-interferon-sensitive (HIS) virus with its IFN-modulating functions removed. These IFN-sensitive HIS viruses induce a strong IFN response upon infection of conventional cells, leading to viral attenuation.
