Fig. 3: Robust vaccine-specific Fc effector functions in STM patients underpinned by a robust anti-S2 IgG response.

Radar plots depicting median ancestral SARS-CoV-2 antigen-specific FcγR and C1q engagement one month post A two BNT162b2 and two BNT162b2 plus mRNA booster (red) or B two AZD1222 doses and two AZD1222 doses plus mRNA booster (blue). Responses normalized to maximum MFI per Fc feature—determined across control and STM cohorts and timepoints within each vaccine regimen—and depicted as percentiles. C SARS-CoV-2 antigen-specific IgG1 responses and D S2/S1 IgG1, FcγRIIaH, and FcγRIIIaV ratios one month post indicated vaccine regimen. E Proportion of vaccinees for whom responses were detected for the indicated number of functions (including neutralization, FcγRIIaH, FcγRIIIaV, and C1q engagement). Number in the center of each pie chart indicates the polyfunctionality index calculated as described in methods. Box plots represent median and IQR. In C horizontal dotted lines indicate positivity threshold. In E statistical differences in proportions of vaccinees with detectable responses for the indicated number of functions determined via chi-square test. Unpaired, nonparametric rank order comparisons between STM and control vaccinees within each vaccinee regimen determined via Mann-Whitney U-tests. P < 0.0001 (****); P < 0.001 (***); P < 0.01 (**); P < 0.05 (*); non-significant (ns). MFI: median fluorescence intensity.