Table 3 Antibody GMT at different time points before and after immunization in different age groups and all participants
Group | Sampling Time points | 40–49 years old | 50–59 years old | 60–69 years old | Total | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | GMT (1/) | 95% CI | N | GMT (1/) | 95% CI | N | GMT (1/) | 95% CI | N | GMT (1/) | 95% CI | ||
LJEV | Day 0 | 51 | 8.50 | 6.71–10.75 | 55 | 12.55 | 9.28–16.97 | 54 | 14.32 | 10.94–18.75 | 160 | 11.59 | 9.90–13.56 |
Day 8 after Dose1 | 49 | 14.24 | 10.45–19.42 | 54 | 21.05 | 15.25–29.06 | 53 | 21.35 | 15.74–28.97 | 156 | 20.20 | 17.60–23.20 | |
Day 29 after Dose1 | 51 | 25.20 | 18.03–35.21 | 54 | 26.19 | 18.83–36.41 | 53 | 23.25 | 16.78–32.22 | 158 | 25.13 | 21.51–29.35 | |
1 year later | 50 | 19.72 | 14.26–27.29 | 50 | 23.62 | 16.99–32.84 | 55 | 25.41 | 18.91–34.15 | 155 | 22.87 | 19.12–27.36 | |
IJEV-IJEV (7 days) | Day 0 | 49 | 11.52 | 8.67–15.31 | 53 | 10.27 | 7.90–13.34 | 53 | 17.78 | 13.28–23.81 | 155 | 12.85 | 10.92–15.11 |
Day 8 after Dose1 | 46 | 22.22 | 15.84–31.19 | 51 | 16.54 | 12.48–21.91 | 51 | 27.71 | 20.85–36.84 | 148 | 21.66 | 18.22–25.75 | |
Day 29 after Dose2 | 49 | 31.45 | 22.14–44.67 | 48 | 22.13 | 15.96–30.68 | 54 | 38.49 | 27.30–54.27 | 151 | 30.23 | 24.85–36.78 | |
1 year later | 48 | 27.09 | 19.19–38.23 | 49 | 19.44 | 14.27–26.49 | 45 | 41.25 | 28.46–59.80 | 142 | 27.60 | 22.63–33.67 | |
IJEV-IJEV (28 days) | Day 0 | 49 | 10.73 | 8.32–13.84 | 52 | 12.88 | 9.63–17.24 | 51 | 13.12 | 10.32–16.69 | 152 | 12.22 | 10.53–14.19 |
Day 29 after Dose1 | 46 | 25.45 | 18.71–34.62 | 52 | 21.96 | 16.33–29.52 | 49 | 19.17 | 14.76–24.90 | 147 | 21.98 | 18.66–25.89 | |
Day 29 after Dose2 | 47 | 26.86 | 19.24–37.49 | 50 | 34.47 | 24.93–47.66 | 51 | 23.54 | 17.74–31.24 | 148 | 27.92 | 23.36–33.38 | |
1 year later | 47 | 22.84 | 16.94–30.80 | 52 | 24.43 | 17.98–33.19 | 50 | 23.62 | 17.75–31.43 | 149 | 23.65 | 19.99–27.97 | |
Control | Day 0 | 52 | 7.56 | 6.19–9.23 | 52 | 16.38 | 12.29–21.82 | 52 | 14.72 | 11.51–18.82 | 156 | 12.21 | 10.52–14.18 |
Day 29 | 52 | 10.13 | 7.90–13.00 | 51 | 18.69 | 14.13–24.7 | 52 | 14.72 | 11.51–18.82 | 155 | 14.05 | 12.08–16.34 | |
Day 58 | 53 | 10.13 | 7.94–12.93 | 52 | 20.27 | 15.21–27.01 | 50 | 18.40 | 14.02–24.15 | 155 | 15.50 | 13.22–18.17 | |
1 year later | 53 | 10.82 | 8.35–14.01 | 52 | 20.00 | 14.84–26.96 | 52 | 19.22 | 15.07–24.5 | 157 | 16.04 | 13.7–18.77 | |
Total | Day 0 | 201 | 9.40 | 8.32–10.61 | 212 | 12.82 | 11.13–14.77 | 210 | 14.91 | 13.10–16.97 | 623 | 12.20 | 11.30–13.18 |