Fig. 1: Circumsporozoite Epitope Regions. | npj Vaccines

Fig. 1: Circumsporozoite Epitope Regions.

From: mRNA delivery of circumsporozoite protein epitope-based malaria vaccines induces protection in a mouse model

Fig. 1: Circumsporozoite Epitope Regions.

a N-terminal domain divided into five linear epitopes, termed P1, P2, P8, P9, and P15. Repeat epitopes divided into four peptides, J2, J3, J3R3, and (NANP)6. C-terminal domain sequence shown. b Model of J3R3 (magenta) displayed on 60mer lumazine synthase nanoparticle (grey). c Model of J3R3 (magenta) displayed on 24mer ferritin nanoparticle (grey). d Schematic of junctional peptide (magenta) displayed on GPI anchor with T-help linker. e Schematic of junctional peptide (magenta) displayed on transmembrane domain with T-help linker.

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