Fig. 3: The fusion inhibition activity of NiV mAbs. | npj Vaccines

Fig. 3: The fusion inhibition activity of NiV mAbs.

From: Antigenic landscape of Nipah virus attachment glycoprotein analysis reveals a protective immunodominant epitope across species

Fig. 3

NiV G/F-mediated cell-cell fusion was determined by a dual split protein (DSP) assay in 293 T cells. A–E Fusion inhibition profiles of NiV mAbs quantified by luciferase activity. Three independent experiments were performed in duplicate, and representative results are shown. Each symbol represents the mean ± SEM. Three previously reported mAbs (HENV-26, nAH1.3, and HENV-32) are indicated by black hollow circles. F, G Fusion activity in the presence of NiV mAbs from groups 1–5 at 1 μg/mL (F) or 10 μg/mL (G) was quantified by GFP signal. Three independent experiments were performed in duplicate, and representative results are shown.

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