Fig. 6: Group 3 mAb LN1F9 shares epitopes with human and macaca mAbs.

A–F Structural comparisons of mAbs targeting the G^H of NiV and HeV. The mAb groups were defined based on the superimposition of the complexes, using G^H as a reference. Receptor ephrin-B2 (PDB: 2VSM) is displayed as a cartoon and colored palegreen. Group 3 mAbs: HENV26 (PDB: 6VY5), m102.3 (PDB: 6CMG), 41-6 (PDB: 8K3C), 1E5 (PDB: 8K0D), and LN1F9 are shown as cartoons in green, teal, lightteal, smudge and green, respectively. Group 1 mAb S1E2 is in blue, group 2 mAb S2B10 is in yellow, group 4 mAbs LN3D3 and nAH1.3 (PDB: 7TXZ) are in red and salmon, group 5 mAbs HENV32 (PDB: 6VY4) and n425 (PDB: 8XPS) are in cyan and palecyan, and group 6 mAb hAH1.3 is in magenta. G Sequence alignment of G^H from NiV and HeV, with structurally defined epitopes highlighted. The binding footprints of group 3 mAbs are colored green and the other groups are colored as in panel (A). The amino acids recognized by ephrin-B2 are marked with a black triangle below the sequence, and the common footprints recognized by ephrin-B2 and group 3 mAbs are indicated with red boxes.