Fig. 2: Three mRNA vaccines induce potent immune responses in mice. | npj Vaccines

Fig. 2: Three mRNA vaccines induce potent immune responses in mice.

From: mRNA-lipid nanoparticle vaccines provide protection against lethal Nipah virus infection

Fig. 2: Three mRNA vaccines induce potent immune responses in mice.The alternative text for this image may have been generated using AI.

a Immunization schedule in mice. Mice received a prime (day 0) and a booster (day 21) intramuscular injection of 5 μg per dose. b, c The F- and G-specific antibody titers of the sera from mice immunized with mRNA-G-LNP, mRNA-GF-LNP, or mRNA-F-LNP at 7, 21, 42, and 98 days post immunization. d, e Kinetics of F- and G-specific antibody titers measured by ELISA. f The neutralization antibodies in the sera of mice collected at 7, 21, and 42 days post prime immunization by pseudovirus neutralization assays. g IFN-γ production induced by the three vaccines detected by ELISpot at 21 days after the second immunization. Data are presented as mean ± SEM. Statistical significance was determined by one-way ANOVA with Tukey’s multiple-comparison test (b, c, f) and Student’s two-tailed t-test (g). *P < 0.05, **P < 0.01, ns, not significant. L.O.D. represents limit of detection.

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