Table 1 Components of the intranasal formulations

From: An innovative nasal nanovaccine against SARS-CoV-2 induces systemic and upper airway immunity controlling viral replication

Vaccine component

Formulation

Purpose

Placebo

Ag-Adjv

MaP vaccine

SiNP vaccine

SiNP-MaP vaccine

RBD

✗

✔

✔

✔

✔

Recombinant antigen

Peptides

✗

✔

✔

✔

✔

Multi-epitope antigen

Poly(I:C)

✔

✔

✔

✔

✔

TLR3 adjuvant

SiNP

✔

✗

✗

✔

✔

Silica nanocarrier

MaP

✔

✗

✔

✗

✔

Polymeric excipient

  1. Ag antigens, Adjv adjuvant, SiNP silica-based nanoparticle, MaP mucoadhesive polymer, RBD receptor binding domain, poly(I:C) poly(inosine:cytidine), TLR3 Toll-like receptor 3.
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